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Although these findings explore surrogate endpoints for liver disease, the results offer a promising future for tirzepatide in NASH and NAFLD populations

In the pivotal SURMOUNT trials evaluating tirzepatide for weight management, participants experienced average systolic blood pressure reductions of 6-8 mmHg and diastolic reductions of 2-4 mmHg compared to placebo over 72 weeks

Studies show that even small temperature variations can affect how these medications function in the body

The PIONEER 7 trial confirmed the pattern with flexibly dosed oral semaglutide, reporting a mean body weight reduction of 2.9 kg vs 0.8 kg for sitagliptin at 52 weeks